Read the original article on American Chemical Society (ACS). Although this study is a promising proof of concept, the microrobots need to be made even smaller to navigate actual blood vessels, and a suitable imaging method needs to be identified to track their movements in the body, the researchers say. When they lowered the pH of the surrounding solution, the fish opened its mouth to release a chemotherapy drug, which killed nearby cells. The team showed that they could steer the fish through simulated blood vessels to reach cancer cells at a specific region of a petri dish. For example, a fish-shaped microrobot had an adjustable “mouth” that opened and closed. The researchers demonstrated various capabilities of the microrobots in several tests. Then, they made the microrobots magnetic by placing them in a suspension of iron oxide nanoparticles. By adjusting the printing density at certain areas of the shape, such as the edges of the crab’s claws or the butterfly’s wings, the team encoded pH-responsive shape morphing. So the researchers 4D printed microrobots in the shape of a crab, butterfly or fish using a pH-responsive hydrogel. Because tumors exist in acidic microenvironments, the team decided to make the microrobots change shape in response to lowered pH. In a step toward biomedical applications for these devices, Jiawen Li, Li Zhang, Dong Wu and colleagues wanted to develop shape-morphing microrobots that could be guided by magnets to specific sites to deliver treatments. Some groups have made 4D-printed objects (3D-printed devices that change shape in response to certain stimuli), but they typically perform only simple actions, and their motion can’t be controlled remotely. Scientists have previously made microscale (smaller than 100 µm) robots that can manipulate tiny objects, but most can’t change their shapes to perform complex tasks, such as releasing drugs. Now, in a proof-of-concept study, researchers reporting in ACS Nano made fish-shaped microrobots that are guided with magnets to cancer cells, where a pH change triggers them to open their mouths and release their chemotherapy cargo. Delivering drugs directly to cancer cells could help reduce these unpleasant symptoms. The wing tips are goldplated with fake gold of course then turquoise enamel frames are embellished with gradient cloisonne cherry blossoms or orchids.Īnother one with cream frames and neon pink or pinkish gold wingtips.ĪND THAT is the end of me sharing a few of my design dreams and ideas.Chemotherapy successfully treats many forms of cancer, but the side effects can wreak havoc on the rest of the body. If I knew where I could have these made if I could afford, I would have these frames made. I thought of different modern items I could use it on and I thought a pair of sunnies or glasses would be so pretty if the frames were done in the super delicate cloisonne technique so here are my sample sketches… I just thought the cloisonne techniques was so pretty but seemed so impractical and out of reach because it was always the vases and plates done in this style. It was essentially what I imagined except it was attached to the face through some sort of suction or adhesive.ĬOSTUME GOLD GLASSES WITH CLOISONNE ENAMEL BUTTERFLY FRAMES And it was possible as I saw accidentally in a makeup tute I spotted on my favorite makeup blog run by Lisa Eldridge. I saw a lot of cutout jelly items out there so I knew it was possible. I also wanted a way to turn my intricate doodles into actual facial wear so cutout jelly was my solution. It would take the shape of a mask but be cut out into intricate patterns that framed the face nicely and it would be punctured on the sides to accommodate a string that would allow it to be attached to the face. I thought jelly could be molded into different shapes and stencils so why not create a mask for the face with it. I was simply bored with the usual masks offered in the market. The most intuitive and direct engineering application of folded-sheet geometries is to produce foldable structures or machines that use the well-understood folding motions of origami. This origami pocket adds more authentic Japanese flavor while serving an important feature. report on origami morphing structures, and on page 647, Silverberg et al. Flat origami pieces are great for simple surface embellishments. I was just trying to make a harajuku-style bag that was quirky but still doable and fairly easy to produce. The following Hello Kitty origami inspired my next idea. PATENT LEATHERETTE BAG WITH ORIGAMI KITTEN POCKETS I decided to put electroplated gold tips on traditional velvet gloves as alternative finger-elongating jewelry. Gloves typically hide fingernails, which is a shame since they elongate our hands and make them more feminine.
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